Weight loss

Semaglutide Compound vs. Ozempic: What is the Difference?

Compounded Semaglutide can be superior to Ozempic if doses are individualized and ingredients are added for increased efficiency and reduced side effects.

Jack & Jill

Medically Reviewed By Mostafa Elhennawy MS, Pharm D

September 16, 2024

Novo Nordisk is the only company in the USA with FDA-approved products (Ozempic, Wegovy, and Rybelsus) containing Semaglutide, a GLP-1 receptor agonist.

Increasing demand that has led to shortages and high cost for injectable anti-obesity drugs have driven patients to seek alternatives resulting in the growth of compounding pharmacies selling bespoke versions as a substitute for weight loss drugs.

The FDA permits compounding of Semaglutide due to shortages or when commercially available medication is not suitable for a particular patient but only if compounding pharmacies and outsourcing facilities are regulated by Section 503A and Section 503B of the Federal Food, Drug, and Cosmetic Act.

In this article, we will focus on the pros and cons of using Compounded Semaglutide and its branded counterpart Ozempic.

About the Experts

We champion clinical excellence through evidence-based, personalized care. We are also commited to affordable clinically-led care for everyone. With features like same day doctor appointments, judgement free care, 24/7 medical chat support, 50+ pharmacy providers, free shipping we are on to something.

Semaglutide

starting at $248 /mo

Why is Semaglutide getting so popular right now?

Because it works. 92% members have achieved lasting weight loss.

Is Compounded Semaglutide the Same As Ozempic?

Compounded Semaglutide (cSemaglutide), produced by a reliable compounding pharmacy, should have the same efficacy and side effects as its commercial counterpart. Its strength can be adjusted compared to standard formulation and certain ingredients can be removed or added to ease side effects to meet an individual’s needs.

Is Compounded Semaglutide Safe?

It is highly recommended to consult the doctor about compounding pharmacies they’ve previously worked with and to ask pharmacies about the tests performed on their sterile products. The legitimacy of the source can be checked on these websites:

Recent safety concerns regarding cSemaglutide are:

The FDA issued an alert related to overdoses due to patients measuring and self-administering incorrect doses and healthcare providers miscalculating doses of the drug.
The FDA alerted the public about the use of Semaglutide salts which are not meeting the requirements for compounded medications.

Weight Loss Reviews

“I’ve been on the weight loss program for a couple of months now, and I’m down 33 lbs”

Tyler

“The biggest change was a decrease in my appetite. It just clicked – this was the missing ingredient in my weight loss journey.”

Verified Jack&Jill member

Janice

“This medication has allowed me to continue with minimal disruptions to my daily life other than an actual injection!”

Verified Jack&Jill member

Angela

“I’ve lost 15lbs of weight loss so far, (am targeting 40-50 lbs in total). I have been extremely happy with the help and assistance from the Jack & Jill Health team so far!”

Verified Jack&Jill member

J.G.

“It is easy to use as it is accessible from home and prescriptions are delivered straight to my door. The medication is personalized to my needs and goals and allows me to have a better lifestyle.”

Verified Jack&Jill member

Peter

“So far I’ve lost 22 pounds. This was the motivation I required to get my life back on track and get active again. Great thing with this medication is I’m able to still eat and drink (moderately) how ever I did before”

Verified Jack&Jill member

“I’m very happy with the customer service I’ve been receiving, prescriptions always come on time”

Jenn

“It’s conveniently shipped to your door and no time wasted going to sit in a doctor’s office. There is a personalized profile you log into with a medical chat if you have questions.”

Verified Jack&Jill member

M.B

“I stand here 15 lbs lighter, feeling healthier, more energetic, and more positive about reaching my weight loss goal than I’ve ever been. And the amazing part is that it has only been just over one month!”

Verified Jack&Jill member

Roman

“I was able to lose over 20 pounds, significantly lower my cholesterol levels, and transition from pre-diabetes to a normal range. I am genuinely blown away by the expertise and support provided by the entire staff”

Verified Jack&Jill member

Kassandra

“Their unwavering support has been incredible. The team’s chats and guidance have been instrumental in helping me regain control of my health.”

Verified Jack&Jill member

Melissa

“I have lost 15 lbs and am well on my way to my goal. The support and ease of use works great for me. Discreet packaging and fast shipping.”

Verified Jack&Jill member

What is the Difference Between Compound Semaglutide and Ozempic?

cSemaglutide can be superior to Ozempic if doses are individualized and ingredients are added for increased efficiency and reduced side effects.

Effectiveness

Semaglutide has demonstrated significant weight loss effects – a reduction of around 15% of initial body weight 68 weeks after initiating treatment.

Form And Dosage

Ozempic is available as multiple-dose pre-filled pens for single-patient use, while a specific concentration of cSemaglutide is delivered in a vial.

The initial dose for both medications is 0.25 mg injected subcutaneously once weekly for 4 weeks.
The dosage for the next month is 0.5 mg once weekly.
This subsequent dosage is 1 mg once weekly for the whole month.
The maximum recommended dosage of 2 mg once weekly can be prescribed after at least 4 weeks on the 1 mg dosage.

A Semaglutide dosage chart can provide valuable insights into dosing variations. Understanding the appropriate dosage is crucial for effective treatment. Refer to this detailed Semaglutide dosage chart to ensure you are following the correct dosing guidelines for compounded Semaglutide.

Storage

It is of great importance to store Semaglutide properly to ensure maximum efficacy and safety:

Unopened Ozempic pens should be stored in the refrigerator (2°- 8°C), while pens in use can be kept for 56 days at room temperature (15°-30°C ) away from excessive heat and sunlight or in a refrigerator.
cSemaglutide stored in the refrigerator lasts up to a month, whereas it can retain stability at higher temperatures (40°C) for up to three days.

Cost

The cost of Ozempic is ~$1000/month while cSemaglutide can cost $200-500/month depending on dosage, vial size, additional ingredients, insurance coverage, manufacturer discount, and pharmacy coupons. When evaluating the cost-effectiveness of different treatments, comparing compounded options can be insightful. Check out our analysis of Zepbound vs compounded Tirzepatide to see which offers better value and results.

Compounded Semaglutide Dosage Chart for Weight Loss

A Compounded Semaglutide Dosage Chart is a crucial tool for individuals looking to manage obesity through pharmacotherapy, particularly in the United States where obesity rates are among the highest globally. This chart provides a detailed guide on how to gradually increase the dosage of semaglutide, a medication approved for weight management, to maximize its effectiveness while minimizing potential side effects.

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How to Store Compound Tirzepatide: Fridge vs. Room Temperature

As tirzepatide becomes increasingly prescribed, understanding its specific storage requirements is very important. Whether in vials, syringes, or injection pens, tirzepatide injections are highly sensitive to temperature changes. They must be refrigerated prior to use and can only stay out of the fridge for a limited period and under specific conditions.

Compound Semaglutide Overview: Where To Buy, Safety, and Side Effects

Semaglutide, a glucagon-like peptide-1 receptor agonist, was primarily a drug in diabetes therapy that was subsequently FDA approved for long-term weight management, cardiovascular risk reduction and nonalcoholic fatty liver disease in patients with HIV. The FDA permits the compounding of Semaglutide due to shortages but only if the product is compounded by pharmacies following the regulations contained in Section 503A of the Federal Food, Drug and Cosmetic Act (FD&C Act).In this article we will cover how to obtain Compounded Semaglutide (CS), its potential side effects, who is eligible for using CS for weight loss and what are unauthorized forms of CS.

When Do Doctors Prescribe Ozempic for Weight Loss?

Ozempic, initially approved as a medication for managing type 2 diabetes, has also gained significant attention for its role in weight loss. Prescribed by doctors under specific circumstances, Ozempic can be a part of a comprehensive weight management plan, particularly for individuals struggling with clinical obesity. Its active ingredient, semaglutide, has been shown to affect appetite and calorie intake, contributing to weight reduction.

5 Best Ozempic Alternatives to Consider for Weight Loss

Ozempic and Mounjaro are FDA approved medications for Type 2 diabetes treatment that are helping lose weight due to their weight management capability. FDA approval date for Ozempic was December 5, 2017, and for Mounjaro May 13, 2022. In this article we will explore their differences in various contexts relevant to patients.

What are Ozempic Ingredients?

Ozempic is a popular medication primarily used for managing type 2 diabetes and, more recently, for aiding in weight loss. At the core of Ozempic's formulation is the active ingredient semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics the action of the natural hormone GLP-1. Understanding the ingredients of Ozempic is essential for anyone considering or currently using this medication, whether for diabetes management or weight loss. Knowing the active and inactive components helps in identifying potential allergic reactions and understanding how the medication works within the body.

GLP-1 Medications for Weight Loss and Diabetes

Glucagon-like peptide 1 (GLP-1) agonists gained fame as a very effective treatment for people with Type 2 diabetes and/or obese individuals. Despite clinically proven benefits, it is very important to review the patient’s medical history and discuss potential risks with a healthcare provider prior to deciding what weight loss medication is the right choice. In this article we will discuss the most popular weight-controlling GLP-1 medications as well as GLP-1 medications that can be beneficial for Type 1 Diabetes.

Ozempic vs. Wegovy: What is the Difference?

Ozempic and Wegovy are brand names of essentially the same drug produced by Danish drugmaker Novo Nordisk. Ozempic is primarily used for glycemic control in patients with Type 2 diabetes, while Wegovy is prescribed for chronic weight management in children aged 12 and adults with obesity or overweight with at least one weight-related condition. It is important to understand how these two medicines differ in order to make informed health decisions which will be the focus of this article.

What Does Ozempic Look Like: How to Spot Fake Ozempic

Ozempic, a prescription medication widely used for the management of type 2 diabetes, has garnered significant attention for its efficacy in lowering blood sugar levels and aiding weight loss. However, with its rising popularity, the market has seen an influx of counterfeit versions, which pose serious health risks to users. It is crucial for patients and healthcare providers to distinguish genuine Ozempic from these fakes to ensure the safety and effectiveness of the treatment. Ensuring that one receives authentic Ozempic not only safeguards against potential side effects but also guarantees the therapeutic benefits it promises.

, an injectable medicine used to treat Type 2 diabetes.

What Does Mounjaro Look Like? How to Spot a Fake One

Mounjaro, a revolutionary medication approved for the treatment of type 2 diabetes, has gained prominence due to its effectiveness in improving blood sugar levels and aiding in weight loss. As Mounjaro becomes increasingly popular, it also becomes a target for counterfeiters, posing significant risks to patients. Counterfeit medications may contain harmful substances or incorrect doses, leading to potentially dangerous health consequences. Therefore, it is crucial for both patients and healthcare providers to be vigilant about ensuring the authenticity of Mounjaro to safeguard its therapeutic integrity and patient safety.

What is Semaglutide Salt? A Detailed Explanation

Semaglutide salts are essential for managing type 2 diabetes and weight loss. We recognize the importance of effective treatment options in improving health outcomes. This article will guide you through the specifics of semaglutide sodium and semaglutide acetate, highlighting their unique benefits. By exploring these formulations, we can help you make informed decisions about your health. These options not only improve treatment effectiveness but also offer stability and better absorption. Let’s explore how semaglutide salts can enhance your health and support your journey to wellness.

Ozempic and Exercise: Why It Is Critical to Keep Working Out

It’s tempting to let go of a regular exercise routine when you are on ozempic. However, it can cause major health issues if you only rely on ozempic to lose weight. This article aims to guide you on how to effectively combine Ozempic with a regular exercise routine to maximize health benefits. We'll discuss how exercise enhances the effectiveness of Ozempic, best practices for creating a safe and effective workout regimen, and strategies for overcoming common challenges like weight loss plateaus.

Understanding Ozempic After Gastric Bypass: Potential Side Effects

Ozempic after gastric bypass surgery can be a valuable tool for managing weight and blood sugar levels. In this article, we aim to provide a comprehensive overview of how Ozempic can support post-surgery care. We'll cover its uses, efficacy, and safety profile, along with practical tips for minimizing and managing side effects. Our goal is to give you the knowledge needed to make informed decisions about your treatment and work closely with your healthcare provider. By understanding how Ozempic works and how to manage its use, you can better achieve your health goals and maintain your well-being after gastric bypass surgery.

Zepbound Alternatives: Over-the-Counter and Compounded Tirzepatide

Zepbound (Tirzeparide) is injectable glucagon-like peptide (GLP-1) and gastric inhibitory polypeptide (GIP) agonist approved by FDA for use in obese (BMI≥30) or overweight adults (BMI≥27) with at least one weight-related condition who struggle to reduce body weight by changing diet and regular exercise. However, despite the effectiveness proven by clinical studies due to the high cost, side effects and route of administration it might not be suitable for everyone. In this article we will discuss available alternatives: over-the-counter options and compounded Tirzepatide.

Zepbound vs Mounjaro: Choose the Right Medication for You

Zepbound and Mounjaro belong to the class of medication known as GLP-1 receptor agonists which gained fame thanks to their superior control of blood sugar levels and weight loss effects. Zepbound and Mounjaro are essentially the same medicine prescribed for different health conditions. In this article we will review what the differences are and how to choose between them.

Compounded Tirzepatide: Clinical Insights, Side Effects, and Cost

Tirzepatide, a dual GLP-1/GIP receptor agonist, is an injectable prescription medicine FDA approved for Type 2 diabetes treatment (Mounjaro) and weight management (Zepbound). Compounded Tirzepatide, if it is made to be “essentially a copy”, has the same efficacy and side effects as a commercial counterpart for a fraction of the cost. In this article we will discuss Compounded Tirzepatide dosage and administration, potential side effects, safety and legality and how to choose a reliable Compounding pharmacy.

What Does Zepbound Look Like and How to Spot a Fake

This article guides you through identifying real Zepbound from counterfeits. Knowing the differences can protect you from potential health risks associated with fake drugs. Counterfeit medications often look convincing but lack the effectiveness and safety of genuine products. By understanding key features like packaging, documentation, and physical characteristics, you can confidently verify your medication. This article provides practical steps and tips to help you spot fake Zepbound, ensuring you receive safe and effective treatment. Your health and peace of mind are worth the effort.

Ozempic Dosing Guidelines for Effective Weight Loss

Ozempic is FDA approved prescription drug for glycemic control and reduction of the risk of cardiovascular death, heart attack and stroke in adults with Type 2 diabetes and treatment of nonalcoholic fatty liver disease in people with HIV. Ozempic is widely used as an off-label drug for weight management. A health care provider can prescribe a suitable dose of Ozempic according to the patient's medical history, current conditions and allergies. In this article we will discuss recommended Ozempic dosage for weight loss, dosing schedule and adjustments, side effects and cost of Ozempic.

Comparing Weight Loss Injection Options: Types and Costs

Choosing the right weight loss injection can be overwhelming, especially with so many options available. In this article, we will guide you through different types of weight loss injections, their costs, their effectiveness, and what you need to consider to make an informed decision. You'll explore popular injections like Semaglutide, Tirzepatide, and others, discussing how they work, their benefits, and potential side effects. This article’s goal is to help you understand these treatments better, so you can confidently discuss your options with your healthcare provider. Let's dive in and find the best solution for your weight management needs.

Mounjaro vs. Ozempic: What is the Difference?

Which One Should You Choose?

The choice between Semaglutide and Ozempic should be made under professional guidelines. If you’re considering alternatives to Ozempic, it’s helpful to compare compounded options. Explore our comparison of compounded Tirzepatide vs Mounjaro to determine which might be more suitable for your needs.

Frequently Asked Questions

Why Should I Combine Compound Semaglutide with B12?

Semaglutide can cause a vitamin B12 deficiency due to its effects on the gastrointestinal tract. Combining Semaglutide with B12 vitamin enhances the drug’s effectiveness and lessens the side effects.

Can Compound Semaglutide Expire?

Yes. Expired Semaglutide can have reduced potency and pose health risks due to bacterial or fungal growth. Unopened Semaglutide vials should be promptly placed in the refrigerator until use and cannot be heated or frozen. Opened Semaglutide should be stored in the fridge and used within 30 days.

Does Compounded Semaglutide Need to Be Refrigerated?

Semaglutide dispensed as a liquid solution for injection is compounded in a sterile laboratory and must be refrigerated to avoid degradation and bacterial growth.

Key Takeaways

Semaglutide, essentially a copy of Ozempic, is recommended when there is a drug shortage or when the commercial medication needs adjusting for a particular patient. Compounded drugs don’t undergo premarket review for safety, quality, or effectiveness and can pose a risk due to too high of a dosage, too many active ingredients, or containing undisclosed/potentially harmful ingredients. Semaglutide should be as effective as Ozempic with the same side effects unless dosages are adjusted and certain ingredients removed/added to minimize the adverse effects. Semaglutide is best kept refrigerated since exposure to direct sunlight or other heat sources affects the medication’s potency and safety.

Sources

GLP-1 Agonists

Compounded Semaglutide

Storage tips

FDA Drug Shortages

Section 503A of the Federal Food, Drug, and Cosmetic Act

Section 503B of the Federal Food, Drug, and Cosmetic Act

Risk of non-refrigerating Compounded Semaglutide

Safety

Semaglutide with B12

Staby A, Steensgaard DB, Haselmann KF, Marino JS, Bartholdy C, Videbæk N, Schelde O, Bosch-Traberg H, Spang LT, Asgreen DJ. Influence of Production Process and Scale on Quality of Polypeptide Drugs: a Case Study on GLP-1 Analogs. Pharm Res. 2020 Jun 8;37(7):120. doi: 10.1007/s11095-020-02817-9. PMID: 32514880.

Kluger AY, McCullough PA. Semaglutide and GLP-1 analogues as weight-loss agents. Lancet. 2018 Aug 25;392(10148):615-616. doi: 10.1016/S0140-6736(18)31826-9. Epub 2018 Aug 16. PMID: 30122306.