Weight loss

Zepbound vs. Compounded Tirzepatide: Are They Same?

cTirzepatide, custom-made by a pharmacist, plays a crucial role during Zepbound shortages.

Jack & Jill

Medically Reviewed By Mostafa Elhennawy MS, Pharm D

December 17, 2024

Eli Lilly’s Zepbound, an injectable prescription weight loss medication containing Tirzepatide, is clinically proven to lead to a substantial reduction of body weight.

Compounded Tirzepatide (cTirzepatide) has grown in popularity due to the limited availability of Zepbound which has been on the FDA’s shortage list for months.

This opened an opportunity for pharmacies, IV infusion clinics, telehealth entrepreneurs and medical spas to fill the gap by producing cTirzepatide, “essentially a copy” of its commercial counterpart for a fraction of the cost.

In this article, we will outline the differences between cTirzepatide and Zepbound.

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Semaglutide

starting at $248 /mo

Why is Semaglutide getting so popular right now?

Because it works. 92% members have achieved lasting weight loss.

What are Zepbound and Compounded Tirzepatide?

Zepbound is:

The FDA approved treatment for weight management in adults who are obese (BMI≥30) or overweight (BMI≥27) with at least one weight-related condition.
A highly effective medication that leads to up to 25% of weight loss in certain adults with obesity (on average 20.9% loss of initial body weight).
Exerting beneficial effects in chronic kidney disease patients, reduces severity of sleep apnea symptoms and decreases several markers associated with cardiovascular risk, such as LDL cholesterol.

cTirzepatide is:

An effective substitute/equivalent of branded medicine custom-made by pharmacists.
Produced if its active ingredients are on the FDA’s shortage list.

Weight Loss Reviews

“I’ve been on the weight loss program for a couple of months now, and I’m down 33 lbs”

Tyler

“The biggest change was a decrease in my appetite. It just clicked – this was the missing ingredient in my weight loss journey.”

Verified Jack&Jill member

Janice

“This medication has allowed me to continue with minimal disruptions to my daily life other than an actual injection!”

Verified Jack&Jill member

Angela

“I’ve lost 15lbs of weight loss so far, (am targeting 40-50 lbs in total). I have been extremely happy with the help and assistance from the Jack & Jill Health team so far!”

Verified Jack&Jill member

J.G.

“It is easy to use as it is accessible from home and prescriptions are delivered straight to my door. The medication is personalized to my needs and goals and allows me to have a better lifestyle.”

Verified Jack&Jill member

Peter

“So far I’ve lost 22 pounds. This was the motivation I required to get my life back on track and get active again. Great thing with this medication is I’m able to still eat and drink (moderately) how ever I did before”

Verified Jack&Jill member

“I’m very happy with the customer service I’ve been receiving, prescriptions always come on time”

Jenn

“It’s conveniently shipped to your door and no time wasted going to sit in a doctor’s office. There is a personalized profile you log into with a medical chat if you have questions.”

Verified Jack&Jill member

M.B

“I stand here 15 lbs lighter, feeling healthier, more energetic, and more positive about reaching my weight loss goal than I’ve ever been. And the amazing part is that it has only been just over one month!”

Verified Jack&Jill member

Roman

“I was able to lose over 20 pounds, significantly lower my cholesterol levels, and transition from pre-diabetes to a normal range. I am genuinely blown away by the expertise and support provided by the entire staff”

Verified Jack&Jill member

Kassandra

“Their unwavering support has been incredible. The team’s chats and guidance have been instrumental in helping me regain control of my health.”

Verified Jack&Jill member

Melissa

“I have lost 15 lbs and am well on my way to my goal. The support and ease of use works great for me. Discreet packaging and fast shipping.”

Verified Jack&Jill member

Difference Between Zepbound and Compounded Tirzepatide

Regulatory aspects and manufacturing processes are different for Zepbound and cTirzepatide.

On the federal level, compounding pharmacies (make medications for specific patients) and outsourcing facilities (bulk manufacturing medications) are regulated by Section 503A and Section 503B of The FDA Food, Drug, and Cosmetic Act, respectively. Compounders must comply with high standards for quality of ingredients and sanitary manufacturing conditions, but they are not obliged to register with the FDA. Licensing and oversight of compounding pharmacies falls to states.

Chemical Composition and Formulation

Essentially, Zepbound and cTirzepatide should have the same chemical composition:

Tirzepatide is a dual GLP-1/GIP agonist, more potent than Novo Nordisk’s GLP-1 agonist Semaglutide. GLP-1 is enhancing insulin secretion and inhibiting glucagon release while simultaneously delaying gastric emptying. GIP enhances GLP-1 effects, aids fat burning and stimulates brain areas that control appetite and satiety.
Pharmacists create cTirzepatide by reformulating the active ingredients in a commercial drug.

However, formulation differs to certain extent:

All ingredients listed in the Zepbound’s labeling are standardized and the same in each injection.
cTirzepatide can contain additional ingredients, such as vitamin B12, that enhance the drug’s effectiveness.

For insights into the storage requirements of cTirzepatide visit Store Compounded Tirzepatide.

, an injectable medicine used to treat Type 2 diabetes.

Compounded Tirzepatide vs. Mounjaro: What is the Difference?

Tirzepatide and Mounjaro represent the latest advancements in diabetes and obesity management, primarily used in the United States. Tirzepatide, marketed under the name Mounjaro, is a novel medication that targets both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. We aim to provide a clear understanding of what compound medications are, how they are prepared, and who can benefit from them. We highlight the scenarios where customized treatments make a significant difference by exploring the intricacies of compounded drugs versus commercial ones. We will also cover the legal and regulatory frameworks ensuring the safety and efficacy of these medications, and offer guidance on how to find a reputable compounding pharmacy.

Compounded Semaglutide Dosage Chart for Weight Loss

A Compounded Semaglutide Dosage Chart is a crucial tool for individuals looking to manage obesity through pharmacotherapy, particularly in the United States where obesity rates are among the highest globally. This chart provides a detailed guide on how to gradually increase the dosage of semaglutide, a medication approved for weight management, to maximize its effectiveness while minimizing potential side effects.

Semaglutide Compound vs. Ozempic: What is the Difference?

Novo Nordisk is the only company in the USA with FDA-approved products (Ozempic, Wegovy, and Rybelsus) containing Semaglutide, a GLP-1 receptor agonist. Increasing demand that has led to shortages and high cost for injectable anti-obesity drugs have driven patients to seek alternatives resulting in the growth of compounding pharmacies selling bespoke versions as a substitute for weight loss drugs. The FDA permits compounding of Semaglutide due to shortages or when commercially available medication is not suitable for a particular patient but only if compounding pharmacies and outsourcing facilities are regulated by Section 503A and Section 503B of the Federal Food, Drug, and Cosmetic Act. In this article, we will focus on the pros and cons of using Compounded Semaglutide and its branded counterpart Ozempic.

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How to Store Compound Tirzepatide: Fridge vs. Room Temperature

As tirzepatide becomes increasingly prescribed, understanding its specific storage requirements is very important. Whether in vials, syringes, or injection pens, tirzepatide injections are highly sensitive to temperature changes. They must be refrigerated prior to use and can only stay out of the fridge for a limited period and under specific conditions.

Compound Semaglutide Overview: Where To Buy, Safety, and Side Effects

Semaglutide, a glucagon-like peptide-1 receptor agonist, was primarily a drug in diabetes therapy that was subsequently FDA approved for long-term weight management, cardiovascular risk reduction and nonalcoholic fatty liver disease in patients with HIV. The FDA permits the compounding of Semaglutide due to shortages but only if the product is compounded by pharmacies following the regulations contained in Section 503A of the Federal Food, Drug and Cosmetic Act (FD&C Act).In this article we will cover how to obtain Compounded Semaglutide (CS), its potential side effects, who is eligible for using CS for weight loss and what are unauthorized forms of CS.

When Do Doctors Prescribe Ozempic for Weight Loss?

Ozempic, initially approved as a medication for managing type 2 diabetes, has also gained significant attention for its role in weight loss. Prescribed by doctors under specific circumstances, Ozempic can be a part of a comprehensive weight management plan, particularly for individuals struggling with clinical obesity. Its active ingredient, semaglutide, has been shown to affect appetite and calorie intake, contributing to weight reduction.

5 Best Ozempic Alternatives to Consider for Weight Loss

Ozempic and Mounjaro are FDA approved medications for Type 2 diabetes treatment that are helping lose weight due to their weight management capability. FDA approval date for Ozempic was December 5, 2017, and for Mounjaro May 13, 2022. In this article we will explore their differences in various contexts relevant to patients.

What are Ozempic Ingredients?

Ozempic is a popular medication primarily used for managing type 2 diabetes and, more recently, for aiding in weight loss. At the core of Ozempic's formulation is the active ingredient semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics the action of the natural hormone GLP-1. Understanding the ingredients of Ozempic is essential for anyone considering or currently using this medication, whether for diabetes management or weight loss. Knowing the active and inactive components helps in identifying potential allergic reactions and understanding how the medication works within the body.

GLP-1 Medications for Weight Loss and Diabetes

Glucagon-like peptide 1 (GLP-1) agonists gained fame as a very effective treatment for people with Type 2 diabetes and/or obese individuals. Despite clinically proven benefits, it is very important to review the patient’s medical history and discuss potential risks with a healthcare provider prior to deciding what weight loss medication is the right choice. In this article we will discuss the most popular weight-controlling GLP-1 medications as well as GLP-1 medications that can be beneficial for Type 1 Diabetes.

Ozempic vs. Wegovy: What is the Difference?

Ozempic and Wegovy are brand names of essentially the same drug produced by Danish drugmaker Novo Nordisk. Ozempic is primarily used for glycemic control in patients with Type 2 diabetes, while Wegovy is prescribed for chronic weight management in children aged 12 and adults with obesity or overweight with at least one weight-related condition. It is important to understand how these two medicines differ in order to make informed health decisions which will be the focus of this article.

What Does Ozempic Look Like: How to Spot Fake Ozempic

Ozempic, a prescription medication widely used for the management of type 2 diabetes, has garnered significant attention for its efficacy in lowering blood sugar levels and aiding weight loss. However, with its rising popularity, the market has seen an influx of counterfeit versions, which pose serious health risks to users. It is crucial for patients and healthcare providers to distinguish genuine Ozempic from these fakes to ensure the safety and effectiveness of the treatment. Ensuring that one receives authentic Ozempic not only safeguards against potential side effects but also guarantees the therapeutic benefits it promises.

What Does Mounjaro Look Like? How to Spot a Fake One

Mounjaro, a revolutionary medication approved for the treatment of type 2 diabetes, has gained prominence due to its effectiveness in improving blood sugar levels and aiding in weight loss. As Mounjaro becomes increasingly popular, it also becomes a target for counterfeiters, posing significant risks to patients. Counterfeit medications may contain harmful substances or incorrect doses, leading to potentially dangerous health consequences. Therefore, it is crucial for both patients and healthcare providers to be vigilant about ensuring the authenticity of Mounjaro to safeguard its therapeutic integrity and patient safety.

What is Semaglutide Salt? A Detailed Explanation

Semaglutide salts are essential for managing type 2 diabetes and weight loss. We recognize the importance of effective treatment options in improving health outcomes. This article will guide you through the specifics of semaglutide sodium and semaglutide acetate, highlighting their unique benefits. By exploring these formulations, we can help you make informed decisions about your health. These options not only improve treatment effectiveness but also offer stability and better absorption. Let’s explore how semaglutide salts can enhance your health and support your journey to wellness.

Ozempic and Exercise: Why It Is Critical to Keep Working Out

It’s tempting to let go of a regular exercise routine when you are on ozempic. However, it can cause major health issues if you only rely on ozempic to lose weight. This article aims to guide you on how to effectively combine Ozempic with a regular exercise routine to maximize health benefits. We'll discuss how exercise enhances the effectiveness of Ozempic, best practices for creating a safe and effective workout regimen, and strategies for overcoming common challenges like weight loss plateaus.

Understanding Ozempic After Gastric Bypass: Potential Side Effects

Ozempic after gastric bypass surgery can be a valuable tool for managing weight and blood sugar levels. In this article, we aim to provide a comprehensive overview of how Ozempic can support post-surgery care. We'll cover its uses, efficacy, and safety profile, along with practical tips for minimizing and managing side effects. Our goal is to give you the knowledge needed to make informed decisions about your treatment and work closely with your healthcare provider. By understanding how Ozempic works and how to manage its use, you can better achieve your health goals and maintain your well-being after gastric bypass surgery.

Zepbound Alternatives: Over-the-Counter and Compounded Tirzepatide

Zepbound (Tirzeparide) is injectable glucagon-like peptide (GLP-1) and gastric inhibitory polypeptide (GIP) agonist approved by FDA for use in obese (BMI≥30) or overweight adults (BMI≥27) with at least one weight-related condition who struggle to reduce body weight by changing diet and regular exercise. However, despite the effectiveness proven by clinical studies due to the high cost, side effects and route of administration it might not be suitable for everyone. In this article we will discuss available alternatives: over-the-counter options and compounded Tirzepatide.

Zepbound vs Mounjaro: Choose the Right Medication for You

Zepbound and Mounjaro belong to the class of medication known as GLP-1 receptor agonists which gained fame thanks to their superior control of blood sugar levels and weight loss effects. Zepbound and Mounjaro are essentially the same medicine prescribed for different health conditions. In this article we will review what the differences are and how to choose between them.

Compounded Tirzepatide: Clinical Insights, Side Effects, and Cost

Tirzepatide, a dual GLP-1/GIP receptor agonist, is an injectable prescription medicine FDA approved for Type 2 diabetes treatment (Mounjaro) and weight management (Zepbound). Compounded Tirzepatide, if it is made to be “essentially a copy”, has the same efficacy and side effects as a commercial counterpart for a fraction of the cost. In this article we will discuss Compounded Tirzepatide dosage and administration, potential side effects, safety and legality and how to choose a reliable Compounding pharmacy.

What Does Zepbound Look Like and How to Spot a Fake

This article guides you through identifying real Zepbound from counterfeits. Knowing the differences can protect you from potential health risks associated with fake drugs. Counterfeit medications often look convincing but lack the effectiveness and safety of genuine products. By understanding key features like packaging, documentation, and physical characteristics, you can confidently verify your medication. This article provides practical steps and tips to help you spot fake Zepbound, ensuring you receive safe and effective treatment. Your health and peace of mind are worth the effort.

Ozempic Dosing Guidelines for Effective Weight Loss

Ozempic is FDA approved prescription drug for glycemic control and reduction of the risk of cardiovascular death, heart attack and stroke in adults with Type 2 diabetes and treatment of nonalcoholic fatty liver disease in people with HIV. Ozempic is widely used as an off-label drug for weight management. A health care provider can prescribe a suitable dose of Ozempic according to the patient's medical history, current conditions and allergies. In this article we will discuss recommended Ozempic dosage for weight loss, dosing schedule and adjustments, side effects and cost of Ozempic.

Comparing Weight Loss Injection Options: Types and Costs

Choosing the right weight loss injection can be overwhelming, especially with so many options available. In this article, we will guide you through different types of weight loss injections, their costs, their effectiveness, and what you need to consider to make an informed decision. You'll explore popular injections like Semaglutide, Tirzepatide, and others, discussing how they work, their benefits, and potential side effects. This article’s goal is to help you understand these treatments better, so you can confidently discuss your options with your healthcare provider. Let's dive in and find the best solution for your weight management needs.

Mounjaro vs. Ozempic: What is the Difference?

Side Effects and Safety Profiles

In general, Zepbound and cTirzepatide share side effect profile. However, additional ingredients can be added to cTirzepatide to minimize side effects.

The most common side effects which mostly improve over time are nausea, abdominal pain, constipation, diarrhea, vomiting and injection site reactions.

Serious side effects that require immediate medical attention are allergic reactions, kidney and vision problems, pancreatitis, gallbladder disease, hypoglycemia and thyroid tumor.

Usage and Dosage Recommendations

Zepbound is a once-a-week, single-dose injectable pen, while cTirzepatide injections are typically dispensed as vials.

Zepbound and cTirzepatide are administered as a subcutaneous injection in the upper arm, abdomen or thigh on the same day of the week each week.
The starting dose, 2.5 mg/week, is gradually increased by 2.5 mg every 4 weeks until the maintenance dose is reached (5 mg, 10 mg or 15 mg).
cTirzepatide doses can be individualized based on the doctor’s advice.

Cost and Accessibility

The list price for Zepbound is $1,059.87 for a 4-week supply. The final price varies depending on insurance coverage, dosage and treatment plan, the prescribed quantity, availability of savings programs, such as Zepbound Savings Card and pharmacy discounts.
cTirzepatide is $100-$225 per injection depending on the dose.

When exploring options for weight loss treatments, comparing compounded Tirzepatide with Mounjaro can be insightful.

Is Compounded Tirzepatide the Same As Zepbound?

Since cTirzepatide is tailor-made by a pharmacist it is not the same as Zepbound.

Frequently Asked Questions

Is Compounded Tirzepatide As Effective As Zepbound?

Most of the cTirzepatide users are satisfied with the weight loss results, but there are no clinical studies showing its effectiveness.

Is There a Compounded Version of Zepbound?

“Compounded Zepbound” is most likely sourced overseas, typically from China, and not considered safe.

Is Zepbound Pure Tirzepatide?

The preparation method of Tirzepatide for production of Zepbound ensures that the active ingredient is pure.

Key Takeaways

cTirzepatide, custom-made by a pharmacist, plays a crucial role during Zepbound shortages.

Compounders are making their own version of Zepbound by combining pharmaceutical-grade active ingredients with inactive ingredients whose type and amount can vary.

cTirzepatide is not inspected by the FDA for quality, safety or effectiveness.

Patients are responsible to investigate whether the medications they’re taking were made by a licensed and reputable compounder.

Unauthorized and Counterfeit Tirzepatide are illegal and can pose serious health risks.

Sources

Zepbound for Chronic Weight Management

Venniyoor A. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022 Oct 13;387(15):1433-1434. doi: 10.1056/NEJMc2211120. PMID: 36239654.

FDA drug shortages

Fisman EZ, Tenenbaum A. The dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide: a novel cardiometabolic therapeutic prospect. Cardiovasc Diabetol. 2021 Nov 24;20(1):225. doi: 10.1186/s12933-021-01412-5. PMID: 34819089; PMCID: PMC8613929.

‘Compounded’ weight-loss drugs are a growing problem for state regulators

Compounded drug products that are essentially copies