Sildenafil vs. Sildenafil Citrate: What is the Difference?

Viagra, a brand-name sildenafil approved by the FDA for treating erectile dysfunction (ED), contains sildenafil as its active ingredient.

Medically Reviewed By Mostafa Elhennawy MS, Pharm D

Sildenafil and Sildenafil Citrate refer to the same medication, but their names highlight a common difference in how drugs are sometimes labeled or branded. 

Occasionally, a brand name becomes so iconic that it replaces the generic term for an item in everyday language. A similar instance is Viagra or Sildenafil Citrate. Viagra is the brand name for sildenafil citrate, the medication and active ingredient used for treating erectile dysfunction. 

While Viagra is one of the several oral treatment options available, it is particularly well-known. In terms of effectiveness, there is little difference between the brand-name product Viagra and generic sildenafil.

About the Experts

We champion clinical excellence through evidence-based, personalized care. We are also commited to affordable clinically-led care for everyone. With features like same day doctor appointments, judgement free care, 24/7 medical chat support, 50+ pharmacy providers, free shipping we are on to something.

Sildenafil vs. Sildenafil Citrate: What is the Difference?

Sildenafil and Sildenafil Citrate are the same medication. “Sildenafil Citrate” is the full chemical name, while “Sildenafil” is often used interchangeably.

Viagra, the brand name for Sildenafil Citrate, is widely recognized as a treatment for erectile dysfunction. Generic Sildenafil works the same way as Viagra, offering similar effectiveness but often at a lower cost.

Weight Loss Reviews

What is Viagra?

Viagra, also known as sildenafil, was originally developed by scientists at Pfizer in the late 1980s as a potential treatment for hypertension and angina pectoris – a type of chest pain associated with coronary heart disease. At the same time, during clinical trials, it was found to have a minimal effect on angina but a significant effect on erectile function. 

In 1989, the US Food and Drug Administration (FDA) approved Viagra as the first oral treatment for erectile dysfunction (ED), radically changing the approach to the condition and opening up a new avenue for treatment. 

Viagra enhances erectile function primarily through its action on the enzyme phosphodiesterase type 5 (PDE5) found predominantly in the penile tissues. This process facilitates the achievement and maintenance of an erection, providing effective relief from erectile dysfunction.

Related articles

What is Generic Viagra?

Generic Viagra refers to medications that contain the same active ingredient, sildenafil citrate, as the brand-name Viagra. A generic medicine must prove that it is bioequivalent to the branded product, meaning it delivers the same medicinal value in the body as the original formulation.

The US Food and Drug Administration (FDA) approved the first generic version of Viagra in 2017. This approval ensures that the generic medication provides the same quality, strength, route of administration, and intended use as its branded counterpart.

What is Sildenafil?

Sildenafil, chemically known as sildenafil citrate, is a small molecule primarily composed of a pyrazolopyrimidinone structure, which acts as a selective inhibitor of cyclic guanosine monophosphate (cGMP) -specific phosphodiesterase type 5 (PDE5). 

This enzyme inhibition is crucial to sildenafil’s pharmacological effect, as it leads to an increase in cGMP levels in smooth muscle cells, promoting muscle relaxation and vasodilation. Originally developed as a treatment for cardiovascular diseases, sildenafil’s ability to enhance nitric oxide’s effects in the vasculature marks its significant impact on blood flow dynamics.

Viagra vs. Sildenafil (Generic Viagra)

Generally, there are no significant differences between Viagra (sildenafil citrate) and generic sildenafil in terms of their active ingredients; both are essentially the same medication. The primary distinctions lie in marketing strategies and branding. 

However, it is important to note that while Viagra is commonly available in 25mg, 50mg, and 100mg dosages specifically for erectile dysfunction, sildenafil also comes in a 20mg dosage under the brand name Revatio, which is approved for treating pulmonary arterial hypertension in addition to erectile dysfunction.

Visually, Viagra is known as the “little blue pill” and is characterized by its diamond shape. In contrast, generic sildenafil tablets may differ in appearance depending on the manufacturer, typically being off-white or white. 

Perhaps the most critical difference for consumers is the cost. Branded Viagra is significantly more expensive than its generic counterparts. Despite the chemical similarities, the strong brand recognition and longlasting reputation of Viagra allow it to command higher prices. 

While discussing different sildenafil products, it’s worth noting the emergence of new brands that are gaining popularity due to their unique formulations and patient-centric approaches. Learn more about one such innovative product in our detailed Jaxx review.

Side Effects of Viagra vs. Sildenafil

Generally, Viagra and generic sildenafil are well-tolerated, with few severe side effects. The most commonly reported side effects include headaches, indigestion, and facial or bodily flushing, though these are not widespread.

Potential side effects to be aware of are:

  • Headaches
  • Indigestion
  • Flushing
  • Nausea
  • Dizziness
  • Rash
  • Low blood pressure
  • Nasal congestion
  • Back pain
  • Abdominal pain
  • Blurred vision or blue-tinted vision
  • Priapism (an erection lasting longer than four hours)

It is crucial to consult your doctor about any medications you are currently taking before starting Viagra or sildenafil. These drugs can interact with other medications and lead to serious health complications.

If you fall into any of the following categories, it is advised to speak with a healthcare provider, as sildenafil or other PDE5 inhibitors may not be suitable for you:

  • Are over 65 years old
  • Take nitrates, such as nitroglycerin
  • Have an existing heart condition
  • Take alpha blockers for high blood pressure
  • Have been diagnosed with Peyronie’s disease
  • Have tinnitus
  • Have liver or kidney disease
  • Have sickle cell anemia

Viagra and Sildenafil Dosage

Viagra is available in three strengths: 25mg, 50mg, and 100mg, with most patients beginning treatment at 50mg. Sildenafil, the generic equivalent, also comes in 25mg, 50mg, and 100mg tablets. Additionally, a 20mg dosage is available when sildenafil is marketed as the generic form of Revatio, which is FDA-approved for treating pulmonary arterial hypertension (PAH) but can be used off-label for erectile dysfunction (ED).

The question arises, is 20mg of sildenafil (generic Revatio) equivalent to 25mg of Viagra? While a single Revatio tablet contains 20mg, multiple tablets may be prescribed for ED to achieve doses of 40mg, 60mg, 80mg, or even 100mg.

Your healthcare provider will determine the exact dosage of either brand-name Viagra or generic sildenafil suitable for you if you’re prescribed these medications.

Since both brand-name Viagra tablets and generic sildenafil contain the same active ingredient, they are expected to deliver identical results from doses ranging from 25mg to 100mg, typically used for ED.

Both Viagra and sildenafil are most effective when taken at least 30 minutes to an hour before sexual activity, but no more than four hours in advance. They can be taken with or without food, though it’s best to avoid high-fat meals as they can delay the onset of action.

If Viagra or generic sildenafil does not improve your erectile function, do not increase the dosage on your own. Instead, consult your healthcare provider, who may adjust your dosage or suggest an alternative ED medication. While sildenafil and other PDE5 inhibitors like vardenafil (Levitra) function similarly, they differ in dosage, with Levitra typically prescribed in lower doses but not necessarily being stronger than Viagra.

Is Sildenafil the Same As Viagra?

Viagra, a brand-name sildenafil approved by the FDA for treating erectile dysfunction (ED), contains sildenafil as its active ingredient. You might wonder if there’s a difference in quality or safety between generic sildenafil and Viagra when it comes to treating ED.

Most generic sildenafil products are simply labeled as “sildenafil,” though some may carry a different brand name. Regardless of branding, they function identically, providing the same benefits and carrying the same risk of side effects.

The most noticeable difference between them is the cost. In the United States, a single tablet of Viagra can cost as much as USD $90, whereas generic sildenafil can be found online for as low as USD $3 per tablet.

Despite the identical active ingredients, if you’re considering switching from Pfizer’s Viagra to a generic version of sildenafil, it’s crucial to ensure that the dosage of the generic version matches that which your healthcare provider has prescribed.

How to Maximize the Effectiveness of Sildenafil

To maximize the effectiveness of sildenafil in treating erectile dysfunction, it is important to follow specific guidelines. By adhering to these tips, you can enhance your experience with sildenafil and achieve better results in managing erectile dysfunction.

Avoid Alcohol

It’s important to avoid alcohol when taking sildenafil to ensure the medication’s effectiveness. Alcohol acts as a depressant, which can diminish physiological functions and hinder the drug’s performance. Drinking alcohol before or after taking sildenafil may significantly decrease its ability to function effectively.

Quit Smoking

Stopping smoking is crucial for enhancing the effectiveness of sildenafil in treating erectile dysfunction. Smoking constricts blood vessels and impairs blood circulation, which can diminish the performance of sildenafil and reduce its therapeutic effects.

Look Into Your Diet

To boost the effectiveness of sildenafil, adopting a diet aimed at enhancing blood flow and vascular health is beneficial. Including heart-healthy foods that are high in omega-3 fatty acids, like salmon, avocados, and nuts, can improve cardiovascular health and enhance blood circulation. This dietary approach may help increase the efficacy of sildenafil.

Frequently Asked Questions

Why Use Sildenafil Citrate?

Sildenafil Citrate is used primarily to treat erectile dysfunction and pulmonary arterial hypertension. It enhances blood flow to specific areas of the body, facilitating the achievement and maintenance of an erection in ED patients and improving exercise capacity in PAH patients. 

Its effectiveness and established safety profile make it a widely prescribed medication for these conditions.

Is Sildenafil Citrate Good for Heart?

Viagra does not appear to affect heart health significantly. Many people with cardiovascular conditions can take Viagra safely. However, one heart-related risk of taking Viagra is dangerously low blood pressure. If someone has low blood pressure, they should not use Viagra.

Can You Take Sildenafil Citrate Daily?

Technically, it’s possible to take both Viagra and its generic sildenafil on a daily basis. However, a more relevant consideration is whether daily use is the best option for you. If you find yourself needing to take Viagra every day due to frequent sexual activity, it may be worth exploring other treatment options that better suit your lifestyle and needs.

Key Takeaways

  • Sildenafil and Sildenafil Citrate are essentially the same drug, with “Sildenafil Citrate” specifically referring to the salt form used in the medication.
  • Viagra, the brand name for sildenafil citrate, was originally developed for cardiovascular issues but was FDA-approved for erectile dysfunction in 1998 due to its effectiveness in treating that condition.
  • Generic sildenafil offers the same effectiveness as Viagra at a significantly lower cost, primarily due to the absence of branding expenses.

More articles from Jack&Jill

Select your store

United States
Canada

I’m in Canada.

Get matched with licensed treatments and health care providers, where you live.