Weight loss

What is Semaglutide (Ozempic) Made of? Ingredients and Sources

Semaglutide serves as the active ingredient in Ozempic, Wegovy, and Rybelsus.

Jack & Jill

Medically Reviewed By Mostafa Elhennawy MS, Pharm D

February 11, 2025

Semaglutide, commonly marketed under the brand name Ozempic, is a medication used primarily for the treatment of type 2 diabetes. It belongs to a class of drugs known as GLP-1 receptor agonists, which work by mimicking the incretin hormones that the body usually produces to stimulate insulin release in response to meals.

This not only helps to control blood sugar levels but also contributes to weight loss, making it a dual-benefit option for patients managing type 2 diabetes.

Knowing the source of the ingredients can inform healthcare providers and patients about the sustainability and ethical sourcing practices of the manufacturing process, aspects increasingly important to consumer choices and regulatory compliance in the pharmaceutical industry.

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What is Semaglutide?

Semaglutide is a medication classified as a glucagon-like peptide-1 (GLP-1) receptor agonist, used primarily in the management of type 2 diabetes. It works by enhancing the body’s ability to produce insulin, the hormone that regulates blood sugar levels, in response to increased blood glucose.

This mechanism not only aids in controlling blood sugar levels but also slows gastric emptying and reduces appetite, which can contribute to weight loss. Semaglutide is administered via injection and has also been found to have cardiovascular benefits, making it a multifaceted tool in diabetes management.

The development of Semaglutide was part of an expansion in the use of incretin mimetics for diabetes treatment, which began in the early 2000s. It was developed by Novo Nordisk, a global leader in diabetes care, and is a modified form of the human incretin hormone, which is more effective and longer-lasting than naturally occurring peptides.

Semaglutide was approved by the U.S. Food and Drug Administration (FDA) in 2017 for the treatment of type 2 diabetes. Its approval was based on a series of clinical trials that demonstrated significant improvements in blood glucose control and reductions in cardiovascular risk factors among patients with type 2 diabetes.

Weight Loss Reviews

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How Does Semaglutide Work?

Semaglutide operates in the body by mimicking the action of the incretin hormone GLP-1 (glucagon-like peptide-1), which is naturally secreted in response to food intake. As a GLP-1 receptor agonist, Semaglutide binds to and activates GLP-1 receptors in the pancreas, enhancing the release of insulin when blood glucose levels are high.

Additionally, it suppresses the release of glucagon, a hormone that raises blood glucose levels, from the pancreas. These actions together help in lowering blood glucose levels. Semaglutide also acts on the brain to reduce appetite and food intake, contributing to weight loss.

Furthermore, it slows gastric emptying, which helps in reducing the speed at which glucose is absorbed into the bloodstream after eating, aiding in overall glucose management.

While Semaglutide effectively manages blood sugar levels, it’s also recognized for its weight loss benefits. For those interested in understanding how to optimize their diet while using Semaglutide, visit our comprehensive guide on the Semaglutide diet for tailored nutritional advice.

Why Am I Not Losing Weight on Ozempic? 10 Common Reasons

Eli Lilly’s Zepbound, an injectable prescription weight loss medication containing Tirzepatide, is clinically proven to lead to a substantial reduction of body weight. We aim to provide a clear understanding of what compound medications are, how they are prepared, and who can benefit from them. We highlight the scenarios where customized treatments make a significant difference by exploring the intricacies of compounded drugs versus commercial ones. We will also cover the legal and regulatory frameworks ensuring the safety and efficacy of these medications, and offer guidance on how to find a reputable compounding pharmacy.

Ozempic Before and After Pictures: What to Expect

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Zepbound vs. Compounded Tirzepatide: Are They Same?

, an injectable medicine used to treat Type 2 diabetes.

Compounded Tirzepatide vs. Mounjaro: What is the Difference?

Tirzepatide and Mounjaro represent the latest advancements in diabetes and obesity management, primarily used in the United States. Tirzepatide, marketed under the name Mounjaro, is a novel medication that targets both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. We aim to provide a clear understanding of what compound medications are, how they are prepared, and who can benefit from them. We highlight the scenarios where customized treatments make a significant difference by exploring the intricacies of compounded drugs versus commercial ones. We will also cover the legal and regulatory frameworks ensuring the safety and efficacy of these medications, and offer guidance on how to find a reputable compounding pharmacy.

Compounded Semaglutide Dosage Chart for Weight Loss

A Compounded Semaglutide Dosage Chart is a crucial tool for individuals looking to manage obesity through pharmacotherapy, particularly in the United States where obesity rates are among the highest globally. This chart provides a detailed guide on how to gradually increase the dosage of semaglutide, a medication approved for weight management, to maximize its effectiveness while minimizing potential side effects.

Semaglutide Compound vs. Ozempic: What is the Difference?

Novo Nordisk is the only company in the USA with FDA-approved products (Ozempic, Wegovy, and Rybelsus) containing Semaglutide, a GLP-1 receptor agonist. Increasing demand that has led to shortages and high cost for injectable anti-obesity drugs have driven patients to seek alternatives resulting in the growth of compounding pharmacies selling bespoke versions as a substitute for weight loss drugs. The FDA permits compounding of Semaglutide due to shortages or when commercially available medication is not suitable for a particular patient but only if compounding pharmacies and outsourcing facilities are regulated by Section 503A and Section 503B of the Federal Food, Drug, and Cosmetic Act. In this article, we will focus on the pros and cons of using Compounded Semaglutide and its branded counterpart Ozempic.

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How to Store Compound Tirzepatide: Fridge vs. Room Temperature

As tirzepatide becomes increasingly prescribed, understanding its specific storage requirements is very important. Whether in vials, syringes, or injection pens, tirzepatide injections are highly sensitive to temperature changes. They must be refrigerated prior to use and can only stay out of the fridge for a limited period and under specific conditions.

Compound Semaglutide Overview: Where To Buy, Safety, and Side Effects

Semaglutide, a glucagon-like peptide-1 receptor agonist, was primarily a drug in diabetes therapy that was subsequently FDA approved for long-term weight management, cardiovascular risk reduction and nonalcoholic fatty liver disease in patients with HIV. The FDA permits the compounding of Semaglutide due to shortages but only if the product is compounded by pharmacies following the regulations contained in Section 503A of the Federal Food, Drug and Cosmetic Act (FD&C Act).In this article we will cover how to obtain Compounded Semaglutide (CS), its potential side effects, who is eligible for using CS for weight loss and what are unauthorized forms of CS.

When Do Doctors Prescribe Ozempic for Weight Loss?

Ozempic, initially approved as a medication for managing type 2 diabetes, has also gained significant attention for its role in weight loss. Prescribed by doctors under specific circumstances, Ozempic can be a part of a comprehensive weight management plan, particularly for individuals struggling with clinical obesity. Its active ingredient, semaglutide, has been shown to affect appetite and calorie intake, contributing to weight reduction.

5 Best Ozempic Alternatives to Consider for Weight Loss

Ozempic and Mounjaro are FDA approved medications for Type 2 diabetes treatment that are helping lose weight due to their weight management capability. FDA approval date for Ozempic was December 5, 2017, and for Mounjaro May 13, 2022. In this article we will explore their differences in various contexts relevant to patients.

What are Ozempic Ingredients?

Ozempic is a popular medication primarily used for managing type 2 diabetes and, more recently, for aiding in weight loss. At the core of Ozempic's formulation is the active ingredient semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics the action of the natural hormone GLP-1. Understanding the ingredients of Ozempic is essential for anyone considering or currently using this medication, whether for diabetes management or weight loss. Knowing the active and inactive components helps in identifying potential allergic reactions and understanding how the medication works within the body.

GLP-1 Medications for Weight Loss and Diabetes

Glucagon-like peptide 1 (GLP-1) agonists gained fame as a very effective treatment for people with Type 2 diabetes and/or obese individuals. Despite clinically proven benefits, it is very important to review the patient’s medical history and discuss potential risks with a healthcare provider prior to deciding what weight loss medication is the right choice. In this article we will discuss the most popular weight-controlling GLP-1 medications as well as GLP-1 medications that can be beneficial for Type 1 Diabetes.

Ozempic vs. Wegovy: What is the Difference?

Ozempic and Wegovy are brand names of essentially the same drug produced by Danish drugmaker Novo Nordisk. Ozempic is primarily used for glycemic control in patients with Type 2 diabetes, while Wegovy is prescribed for chronic weight management in children aged 12 and adults with obesity or overweight with at least one weight-related condition. It is important to understand how these two medicines differ in order to make informed health decisions which will be the focus of this article.

What Does Ozempic Look Like: How to Spot Fake Ozempic

Ozempic, a prescription medication widely used for the management of type 2 diabetes, has garnered significant attention for its efficacy in lowering blood sugar levels and aiding weight loss. However, with its rising popularity, the market has seen an influx of counterfeit versions, which pose serious health risks to users. It is crucial for patients and healthcare providers to distinguish genuine Ozempic from these fakes to ensure the safety and effectiveness of the treatment. Ensuring that one receives authentic Ozempic not only safeguards against potential side effects but also guarantees the therapeutic benefits it promises.

What Does Mounjaro Look Like? How to Spot a Fake One

Mounjaro, a revolutionary medication approved for the treatment of type 2 diabetes, has gained prominence due to its effectiveness in improving blood sugar levels and aiding in weight loss. As Mounjaro becomes increasingly popular, it also becomes a target for counterfeiters, posing significant risks to patients. Counterfeit medications may contain harmful substances or incorrect doses, leading to potentially dangerous health consequences. Therefore, it is crucial for both patients and healthcare providers to be vigilant about ensuring the authenticity of Mounjaro to safeguard its therapeutic integrity and patient safety.

What is Semaglutide Salt? A Detailed Explanation

Semaglutide salts are essential for managing type 2 diabetes and weight loss. We recognize the importance of effective treatment options in improving health outcomes. This article will guide you through the specifics of semaglutide sodium and semaglutide acetate, highlighting their unique benefits. By exploring these formulations, we can help you make informed decisions about your health. These options not only improve treatment effectiveness but also offer stability and better absorption. Let’s explore how semaglutide salts can enhance your health and support your journey to wellness.

Ozempic and Exercise: Why It Is Critical to Keep Working Out

It’s tempting to let go of a regular exercise routine when you are on ozempic. However, it can cause major health issues if you only rely on ozempic to lose weight. This article aims to guide you on how to effectively combine Ozempic with a regular exercise routine to maximize health benefits. We'll discuss how exercise enhances the effectiveness of Ozempic, best practices for creating a safe and effective workout regimen, and strategies for overcoming common challenges like weight loss plateaus.

Understanding Ozempic After Gastric Bypass: Potential Side Effects

Ozempic after gastric bypass surgery can be a valuable tool for managing weight and blood sugar levels. In this article, we aim to provide a comprehensive overview of how Ozempic can support post-surgery care. We'll cover its uses, efficacy, and safety profile, along with practical tips for minimizing and managing side effects. Our goal is to give you the knowledge needed to make informed decisions about your treatment and work closely with your healthcare provider. By understanding how Ozempic works and how to manage its use, you can better achieve your health goals and maintain your well-being after gastric bypass surgery.

Zepbound Alternatives: Over-the-Counter and Compounded Tirzepatide

Zepbound (Tirzeparide) is injectable glucagon-like peptide (GLP-1) and gastric inhibitory polypeptide (GIP) agonist approved by FDA for use in obese (BMI≥30) or overweight adults (BMI≥27) with at least one weight-related condition who struggle to reduce body weight by changing diet and regular exercise. However, despite the effectiveness proven by clinical studies due to the high cost, side effects and route of administration it might not be suitable for everyone. In this article we will discuss available alternatives: over-the-counter options and compounded Tirzepatide.

Zepbound vs Mounjaro: Choose the Right Medication for You

Zepbound and Mounjaro belong to the class of medication known as GLP-1 receptor agonists which gained fame thanks to their superior control of blood sugar levels and weight loss effects. Zepbound and Mounjaro are essentially the same medicine prescribed for different health conditions. In this article we will review what the differences are and how to choose between them.

Compounded Tirzepatide: Clinical Insights, Side Effects, and Cost

Tirzepatide, a dual GLP-1/GIP receptor agonist, is an injectable prescription medicine FDA approved for Type 2 diabetes treatment (Mounjaro) and weight management (Zepbound). Compounded Tirzepatide, if it is made to be “essentially a copy”, has the same efficacy and side effects as a commercial counterpart for a fraction of the cost. In this article we will discuss Compounded Tirzepatide dosage and administration, potential side effects, safety and legality and how to choose a reliable Compounding pharmacy.

What Does Zepbound Look Like and How to Spot a Fake

This article guides you through identifying real Zepbound from counterfeits. Knowing the differences can protect you from potential health risks associated with fake drugs. Counterfeit medications often look convincing but lack the effectiveness and safety of genuine products. By understanding key features like packaging, documentation, and physical characteristics, you can confidently verify your medication. This article provides practical steps and tips to help you spot fake Zepbound, ensuring you receive safe and effective treatment. Your health and peace of mind are worth the effort.

Ozempic Dosing Guidelines for Effective Weight Loss

Ozempic is FDA approved prescription drug for glycemic control and reduction of the risk of cardiovascular death, heart attack and stroke in adults with Type 2 diabetes and treatment of nonalcoholic fatty liver disease in people with HIV. Ozempic is widely used as an off-label drug for weight management. A health care provider can prescribe a suitable dose of Ozempic according to the patient's medical history, current conditions and allergies. In this article we will discuss recommended Ozempic dosage for weight loss, dosing schedule and adjustments, side effects and cost of Ozempic.

Comparing Weight Loss Injection Options: Types and Costs

Choosing the right weight loss injection can be overwhelming, especially with so many options available. In this article, we will guide you through different types of weight loss injections, their costs, their effectiveness, and what you need to consider to make an informed decision. You'll explore popular injections like Semaglutide, Tirzepatide, and others, discussing how they work, their benefits, and potential side effects. This article’s goal is to help you understand these treatments better, so you can confidently discuss your options with your healthcare provider. Let's dive in and find the best solution for your weight management needs.

Mounjaro vs. Ozempic: What is the Difference?

What is Semaglutide's Active Ingredient?

Semaglutide serves as the active ingredient in Ozempic, Wegovy, and Rybelsus. It is prescribed for weight management in specific patients and to decrease blood sugar levels, as well as to mitigate the risk of major cardiovascular events like heart attacks or strokes in certain individuals. As a GLP-1 agonist, semaglutide functions by enhancing insulin secretion, reducing glucagon release, slowing gastric emptying, and curbing appetite.

Among the brands, Wegovy is distinctively approved by the FDA specifically for weight loss, making it the sole semaglutide-based product designated for this purpose.

Understanding the action of Semaglutide in the body raises questions about its onset of effectiveness. For those curious about how quickly they can expect to see results, read more about how long Semaglutide takes to work, including what factors influence its efficacy.

What are Other Ozempic Ingredients?

The formulation of Ozempic, aside from its active ingredient semaglutide, includes several inactive ingredients that serve various purposes in the medication’s stability, delivery, and absorption. Here’s a list of these ingredients and their functions:

Disodium phosphate dihydrate: Helps in maintaining the pH balance of the solution.
Propylene glycol: Acts as a solvent and stabilizer in the formulation.
Phenol: Used as a preservative to prolong shelf life.
Water for injections: Serves as the solvent in which all the ingredients are dissolved.

Among these components, phenol is notable as it could potentially be a common allergen for some individuals. Additionally, propylene glycol, while generally safe, can sometimes cause irritation or allergic reactions, making these two ingredients particularly important to be aware of if you have sensitivities or allergies.

Dosage for Ozempic

Ozempic is supplied as a pre-filled injection pen and is administered once a week subcutaneously, meaning just under the skin, which can be done in the abdomen, thigh, or upper arm. The timing of your meals does not impact the effectiveness of the dose.

It’s important to choose a consistent day and time each week that fits your schedule to maintain a routine. Initially, Ozempic is started at a dose of 0.25 mg weekly, which is primarily intended to help your body adjust to the medication and mitigate any digestion-related side effects rather than to control blood sugar.

Here’s a breakdown of the typical Ozempic dosing schedule:

Month 1: Start with 0.25 mg once weekly.
Month 2: Increase to 0.5 mg once weekly.
Month 3: Optional increase to 1 mg once weekly.
Month 4 and onward: Optional increase to 2 mg once weekly, depending on your needs and doctor’s advice.

Your usual dosage will likely range from 0.5 mg to 2 mg once weekly, which is the maximum. Always follow your healthcare provider’s specific instructions, which may vary from the general guidelines.

Wegovy, another semaglutide-containing medication, is not for diabetes management but is instead approved for weight loss in individuals with or without Type 2 diabetes. While Ozempic’s maximum dosage is 2 mg weekly, Wegovy can be administered up to 2.4 mg once weekly.

Side Effects of Ozempic

Common side effects experienced by patients using Ozempic include:

Nausea
Vomiting
Diarrhea
Stomach pain
Constipation
Reduced appetite
Heartburn
Injection site reactions

Some side effects may be severe. If you notice any of the following symptoms, contact your doctor immediately or seek emergency medical attention:

Persistent pain in the upper left or middle stomach that may radiate to the back, with or without vomiting
Rash, itching, swelling of the eyes, face, mouth, tongue, or throat, or difficulty breathing or swallowing
Reduced urination, or swelling in the legs, ankles, or feet
Changes in vision
Fainting or dizziness
Pain in the upper stomach, yellowing of the skin or eyes, fever, or clay-colored stools
Rapid heart rate
Dizziness, lightheadedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heart rate, anxiety, irritability or mood changes, hunger, weakness, or feeling jittery.

While most side effects of Ozempic are manageable and often diminish over time, some serious side effects require immediate medical attention. These include signs of pancreatitis such as severe abdominal pain that may radiate to the back, nausea or vomiting that does not stop, and rapid heartbeat.

Frequently Asked Questions

Does Ozempic Contain Preservatives?

Ozempic includes a small quantity of phenol, which serves as a preservative. This addition is crucial because an Ozempic pen is utilized multiple times, and phenol helps inhibit the growth of bacteria and other microbes in the medication throughout its usage.

Can Any Ingredients in Ozempic Cause an Allergic Reaction?

You may experience an allergic reaction to an ingredient in Ozempic. If you have any history of allergies or food sensitivities, it’s important to inform your doctor before starting Ozempic.

Is Ozempic Actually Insulin?

No, Ozempic is not a type of insulin, nor does it replace insulin. However, it does encourage your pancreas to produce insulin when glucose levels rise, such as after eating. Ozempic’s effectiveness depends on your body’s natural insulin production.

Key Takeaways

Semaglutide, the active ingredient in Ozempic, manages blood sugar levels and supports weight loss, offering significant benefits for type 2 diabetes patients.
Knowing the ingredients and their sources in Ozempic helps identify potential allergies and ensures ethical pharmaceutical practices.
Approved by the FDA in 2017, Semaglutide is effective for diabetes management and is also used in other brands like Wegovy for weight loss.