Ozempic vs. Wegovy: What is the Difference?

Research is focused on Ozempic as diabetes medicine and Wegovy as weight loss drug.

Medically Reviewed By Mostafa Elhennawy MS, Pharm D

Ozempic and Wegovy are brand names of essentially the same drug produced by Danish drugmaker Novo Nordisk. 

Ozempic is primarily used for glycemic control in patients with Type 2 diabetes, while Wegovy is prescribed for chronic weight management in children aged 12 and adults with obesity or overweight with at least one weight-related condition. 

It is important to understand how these two medicines differ in order to make informed health decisions which will be the focus of this article.

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Ozempic vs. Wegovy: Is Wegovy the Same As Ozempic?

Ozempic and Wegovy belong to the same class of medication known as GLP-1 receptor agonists but they are different medicines. 

Research is focused on Ozempic as diabetes medicine and Wegovy as weight loss drug. 

Generics

Ozempic and Wegovy contain the same active ingredient – Semaglutide. Semaglutide improves regulation of blood glucose levels and aids to weight loss by boosting insulin release, decreasing glucagon release, slowing down gastric emptying and promoting satiety.

Uses

Semaglutide is also recognized by FDA as a drug that reduces the risk of cardiovascular death, heart attack and stroke in adults with cardiovascular disease and either obesity or overweight. Also, Semaglutide reduces the severity of common liver disease in people with HIV.

Effectiveness

Semaglutide is highly effective in glycemic control and body weight management. Studies showed that Wegovy can reduce body weight to up to 15%.

Dosages, Forms, and Administration

Both Ozempic and Wegovy are injected subcutaneously once a week. Ozempic comes in multidose pens with disposable Novofine needles, whereas Wegovy comes in single-dose one-time use disposable pens. The starting dose for both medicines is 0.25 mg for the first 4 weeks and gradually increases every 4 weeks. 

At week 5 the dose for Ozempic increases to 0.5 mg. If additional blood glucose control is needed Ozempic’s dose can increase to 1 mg or 2mg, which is the maximum dose. 

Wegovy’s dose increases to 0.5 mg at week 5, followed by 1 mg. Maintenance dose can be 1.7 mg or 2.4 mg, depending on efficiency and how well side effects are tolerated. 

The injection site (upper arm, thigh and abdomen) should be rotated each time.

Side Effects

Even though Ozempic and Wegovy have similar side effects profile, the side effects of Wegovy can be more pronounced due to higher dosages. 

Most common side effects include nausea, vomiting, abdominal pain, diarrhea or constipation. 

Serious side effects are swelling of the pancreas, diabetic retinopathy, kidney problems, allergic reactions, acute gallbladder disease and hypoglycemia. 

Possible side effects should be discussed with the health care provider prior to beginning the treatment. In case of any serious side effect the healthcare provider must be contacted immediately.

Cost

The list price for Ozempic is $935.77 for a 4-week supply, while Wegovy costs $1,349.02 for the same period of time. 

Ozempic is covered by most insurance plans if prescribed as diabetes medicine, while off-label prescription for weight loss most likely won’t be covered. The Ozempic Savings Card can help reduce the cost to $25 per month for users of private insurance. Uninsured patients could be eligible for Ozempic at no cost through Novo Nordisk Patient Assistance Program.

The price for Wegovy might drop to $0 for people who have private health insurance or up to $500 for uninsured cash payers. Novo Nordisk offers a savings program for those with private insurance.

Weight Loss Reviews

Can You Switch from Ozempic to Wegovy or Vice Versa?

Ozempic and Wegovy have similarities but they are prescribed for different purposes to different categories of patients in different doses and are not interchangeable. 

Related articles

Frequently Asked Questions

Can You Take Ozempic and Wegovy at the Same Time?

No, taking Ozempic and Wegovy at the same time is very risky due to the overlapping mechanisms of action and different doses which may cause serious side effects.

What is the Strongest Weight Loss Injection?

Wegovy comes in higher doses compared to Ozempic with the 2.4 mg injection pen being the highest dose available.

Is Wegovy a Lifetime Drug?

Once the treatment with Wegovy is stopped withdrawal symptoms occur and eventually lost weight is regained so it can be considered a lifetime drug.

 

 

 

Key Takeaways

Ozempic and Wegovy contain the same active ingredient but they are licensed for different health conditions.

They come in different injection pens, doses and have slightly different side effects.

Insurance coverage differs, with more benefits being available for Ozempic if prescribed as a treatment for Type 2 diabetes.

 

It is crucial to consult a health care provider who will assess a patient’s needs based on a medical history, therapy goals and allergies prior to deciding which medication to take.

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