Ozempic and Wegovy belong to the same class of medication known as GLP-1 receptor agonists but they are different medicines.
Research is focused on Ozempic as diabetes medicine and Wegovy as weight loss drug.
Generics
Ozempic and Wegovy contain the same active ingredient – Semaglutide. Semaglutide improves regulation of blood glucose levels and aids to weight loss by boosting insulin release, decreasing glucagon release, slowing down gastric emptying and promoting satiety.
Uses
Semaglutide is also recognized by FDA as a drug that reduces the risk of cardiovascular death, heart attack and stroke in adults with cardiovascular disease and either obesity or overweight. Also, Semaglutide reduces the severity of common liver disease in people with HIV.
Effectiveness
Semaglutide is highly effective in glycemic control and body weight management. Studies showed that Wegovy can reduce body weight to up to 15%.
Dosages, Forms, and Administration
Both Ozempic and Wegovy are injected subcutaneously once a week. Ozempic comes in multidose pens with disposable Novofine needles, whereas Wegovy comes in single-dose one-time use disposable pens. The starting dose for both medicines is 0.25 mg for the first 4 weeks and gradually increases every 4 weeks.
At week 5 the dose for Ozempic increases to 0.5 mg. If additional blood glucose control is needed Ozempic’s dose can increase to 1 mg or 2mg, which is the maximum dose.
Wegovy’s dose increases to 0.5 mg at week 5, followed by 1 mg. Maintenance dose can be 1.7 mg or 2.4 mg, depending on efficiency and how well side effects are tolerated.
The injection site (upper arm, thigh and abdomen) should be rotated each time.
Side Effects
Even though Ozempic and Wegovy have similar side effects profile, the side effects of Wegovy can be more pronounced due to higher dosages.
Most common side effects include nausea, vomiting, abdominal pain, diarrhea or constipation.
Serious side effects are swelling of the pancreas, diabetic retinopathy, kidney problems, allergic reactions, acute gallbladder disease and hypoglycemia.
Possible side effects should be discussed with the health care provider prior to beginning the treatment. In case of any serious side effect the healthcare provider must be contacted immediately.
Cost
The list price for Ozempic is $935.77 for a 4-week supply, while Wegovy costs $1,349.02 for the same period of time.
Ozempic is covered by most insurance plans if prescribed as diabetes medicine, while off-label prescription for weight loss most likely won’t be covered. The Ozempic Savings Card can help reduce the cost to $25 per month for users of private insurance. Uninsured patients could be eligible for Ozempic at no cost through Novo Nordisk Patient Assistance Program.
The price for Wegovy might drop to $0 for people who have private health insurance or up to $500 for uninsured cash payers. Novo Nordisk offers a savings program for those with private insurance.