Weight loss

GLP-1 Medications for Weight Loss and Diabetes

Wegovy, Zepbound and Saxenda are the most popular among GLP-1 agonists as weight-loss medicines

Jack & Jill

Medically Reviewed By Mostafa Elhennawy MS, Pharm D

September 4, 2024

Glucagon-like peptide 1 (GLP-1) agonists gained fame as a very effective treatment for people with Type 2 diabetes and/or obese individuals.

Despite clinically proven benefits, it is very important to review the patient’s medical history and discuss potential risks with a healthcare provider prior to deciding what weight loss medication is the right choice.

In this article we will discuss the most popular weight-controlling GLP-1 medications as well as GLP-1 medications that can be beneficial for Type 1 Diabetes.

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Semaglutide

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3 Popular Weight Loss GLP-1 Medications

GLP-1 agonists are mimicking the action of a gut-brain hormone GLP-1 that represents an endogenous satiation signal and has widespread metabolic effects, such as promoting glucose homeostasis and weight loss. They are exerting their weight-reducing and glucose-lowering effects by increasing the production of insulin and slowing down the digestion of food. Their effects can vary depending on which GLP-1 is used and dosage so they should be prescribed based on specific patient profile and medical history.

Wegovy (Semaglutide)

Wegovy is FDA approved injectable treatment for weight management and cardiovascular risk reduction in adults with obesity and overweight. Its active ingredient, Semaglutide, reduces cravings and decreases appetite like other GLP-1 agonists, which combined with a healthy diet and regular exercise leads to 10-15% weight loss.

Wegovy comes in 5 different dose strengths taken weekly for 4 weeks each:

0.25 mg is the starting dose
0.5 mg the step up dose
1 mg the step up dose
1.7 mg the maintenance dose
2.4 mg the maintenance dose.

Health provider decides which dose will be used for weight maintenance.

Zepbound (Tirzepatide)

Zepbound is FDA approved powerful appetite-suppressing treatment for obesity or overweight adults that in conjunction with healthy lifestyle changes can help losing up to 25% of initial body weight. Zepbound’s active ingredient, Tirzepatide, is dual GLP-1 and Gastric Inhibitory Peptide (GIP) receptor agonist. Synergistic action of GLP-1 and GIP makes Zepbound more efficacious than Semaglutide.

Zepbound is available in six strengths:

2.5 mg starting dose
5 mg maintenance dose
7.5 mg increasing dose
10 mg maintenance dose
12.5 mg increasing dose
15 mg maintenance dose.

The healthcare provider will start by prescribing the lowest dose which can be increased after 4 weeks of weekly administration. The maintenance dose will be the one that provides the desired effect.

Saxenda (Liraglutide)

Saxenda is FDA approved injectable drug for weight loss suitable for use even in paediatric patients aged 12 years or older whose body weight is more than 60 kg. Saxenda’s active ingredient is Liraglutide which affects satiety and suppresses appetite. The average weight loss following Saxenda treatment, reduced-calorie diet and regular exercise is up to 9.2%.

Saxenda comes in six doses:

0.6 mg starting dose
1.2 mg increasing dose
1.8 mg increasing dose
2.4 mg increasing dose
3 mg maintenance dose.

The healthcare provider will increase the dose weekly. It is expected to experience weight loss after week five, when the body gets used to new medication and good habits (healthy lifestyle) are established.

Weight Loss Reviews

“I’ve been on the weight loss program for a couple of months now, and I’m down 33 lbs”

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Janice

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What are GLP-1 Medications for Type-1 Diabetes?

GLP-1 agonists received attention as off-label Type 1 Diabetes treatment due to suppressing liver glucose production, increasing sensitivity to insulin, slowing down digestion and decreasing appetite and cravings.

Ongoing trials regarding the effects of GLP-1 agonists in people suffering from Type 1 diabetes are:

GLP-1 agonists reduce a person’s need for insulin without significantly increasing hypoglycemia risk. The healthcare provider must carefully adjust doses for both, GLP-1 agonists and insulin, when introducing GLP-1 agonists as a therapy for people already taking insulin or glucose-lowering treatment.

Zepbound vs. Compounded Tirzepatide: Are They Same?

Eli Lilly’s Zepbound, an injectable prescription weight loss medication containing Tirzepatide, is clinically proven to lead to a substantial reduction of body weight. We aim to provide a clear understanding of what compound medications are, how they are prepared, and who can benefit from them. We highlight the scenarios where customized treatments make a significant difference by exploring the intricacies of compounded drugs versus commercial ones. We will also cover the legal and regulatory frameworks ensuring the safety and efficacy of these medications, and offer guidance on how to find a reputable compounding pharmacy.

, an injectable medicine used to treat Type 2 diabetes.

Compounded Tirzepatide vs. Mounjaro: What is the Difference?

Tirzepatide and Mounjaro represent the latest advancements in diabetes and obesity management, primarily used in the United States. Tirzepatide, marketed under the name Mounjaro, is a novel medication that targets both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. We aim to provide a clear understanding of what compound medications are, how they are prepared, and who can benefit from them. We highlight the scenarios where customized treatments make a significant difference by exploring the intricacies of compounded drugs versus commercial ones. We will also cover the legal and regulatory frameworks ensuring the safety and efficacy of these medications, and offer guidance on how to find a reputable compounding pharmacy.

Compounded Semaglutide Dosage Chart for Weight Loss

A Compounded Semaglutide Dosage Chart is a crucial tool for individuals looking to manage obesity through pharmacotherapy, particularly in the United States where obesity rates are among the highest globally. This chart provides a detailed guide on how to gradually increase the dosage of semaglutide, a medication approved for weight management, to maximize its effectiveness while minimizing potential side effects.

Semaglutide Compound vs. Ozempic: What is the Difference?

Novo Nordisk is the only company in the USA with FDA-approved products (Ozempic, Wegovy, and Rybelsus) containing Semaglutide, a GLP-1 receptor agonist. Increasing demand that has led to shortages and high cost for injectable anti-obesity drugs have driven patients to seek alternatives resulting in the growth of compounding pharmacies selling bespoke versions as a substitute for weight loss drugs. The FDA permits compounding of Semaglutide due to shortages or when commercially available medication is not suitable for a particular patient but only if compounding pharmacies and outsourcing facilities are regulated by Section 503A and Section 503B of the Federal Food, Drug, and Cosmetic Act. In this article, we will focus on the pros and cons of using Compounded Semaglutide and its branded counterpart Ozempic.

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How to Store Compound Tirzepatide: Fridge vs. Room Temperature

As tirzepatide becomes increasingly prescribed, understanding its specific storage requirements is very important. Whether in vials, syringes, or injection pens, tirzepatide injections are highly sensitive to temperature changes. They must be refrigerated prior to use and can only stay out of the fridge for a limited period and under specific conditions.

Compound Semaglutide Overview: Where To Buy, Safety, and Side Effects

Semaglutide, a glucagon-like peptide-1 receptor agonist, was primarily a drug in diabetes therapy that was subsequently FDA approved for long-term weight management, cardiovascular risk reduction and nonalcoholic fatty liver disease in patients with HIV. The FDA permits the compounding of Semaglutide due to shortages but only if the product is compounded by pharmacies following the regulations contained in Section 503A of the Federal Food, Drug and Cosmetic Act (FD&C Act).In this article we will cover how to obtain Compounded Semaglutide (CS), its potential side effects, who is eligible for using CS for weight loss and what are unauthorized forms of CS.

When Do Doctors Prescribe Ozempic for Weight Loss?

Ozempic, initially approved as a medication for managing type 2 diabetes, has also gained significant attention for its role in weight loss. Prescribed by doctors under specific circumstances, Ozempic can be a part of a comprehensive weight management plan, particularly for individuals struggling with clinical obesity. Its active ingredient, semaglutide, has been shown to affect appetite and calorie intake, contributing to weight reduction.

5 Best Ozempic Alternatives to Consider for Weight Loss

Ozempic and Mounjaro are FDA approved medications for Type 2 diabetes treatment that are helping lose weight due to their weight management capability. FDA approval date for Ozempic was December 5, 2017, and for Mounjaro May 13, 2022. In this article we will explore their differences in various contexts relevant to patients.

What are Ozempic Ingredients?

Ozempic is a popular medication primarily used for managing type 2 diabetes and, more recently, for aiding in weight loss. At the core of Ozempic's formulation is the active ingredient semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics the action of the natural hormone GLP-1. Understanding the ingredients of Ozempic is essential for anyone considering or currently using this medication, whether for diabetes management or weight loss. Knowing the active and inactive components helps in identifying potential allergic reactions and understanding how the medication works within the body.

Ozempic vs. Wegovy: What is the Difference?

Ozempic and Wegovy are brand names of essentially the same drug produced by Danish drugmaker Novo Nordisk. Ozempic is primarily used for glycemic control in patients with Type 2 diabetes, while Wegovy is prescribed for chronic weight management in children aged 12 and adults with obesity or overweight with at least one weight-related condition. It is important to understand how these two medicines differ in order to make informed health decisions which will be the focus of this article.

What Does Ozempic Look Like: How to Spot Fake Ozempic

Ozempic, a prescription medication widely used for the management of type 2 diabetes, has garnered significant attention for its efficacy in lowering blood sugar levels and aiding weight loss. However, with its rising popularity, the market has seen an influx of counterfeit versions, which pose serious health risks to users. It is crucial for patients and healthcare providers to distinguish genuine Ozempic from these fakes to ensure the safety and effectiveness of the treatment. Ensuring that one receives authentic Ozempic not only safeguards against potential side effects but also guarantees the therapeutic benefits it promises.

What Does Mounjaro Look Like? How to Spot a Fake One

Mounjaro, a revolutionary medication approved for the treatment of type 2 diabetes, has gained prominence due to its effectiveness in improving blood sugar levels and aiding in weight loss. As Mounjaro becomes increasingly popular, it also becomes a target for counterfeiters, posing significant risks to patients. Counterfeit medications may contain harmful substances or incorrect doses, leading to potentially dangerous health consequences. Therefore, it is crucial for both patients and healthcare providers to be vigilant about ensuring the authenticity of Mounjaro to safeguard its therapeutic integrity and patient safety.

What is Semaglutide Salt? A Detailed Explanation

Semaglutide salts are essential for managing type 2 diabetes and weight loss. We recognize the importance of effective treatment options in improving health outcomes. This article will guide you through the specifics of semaglutide sodium and semaglutide acetate, highlighting their unique benefits. By exploring these formulations, we can help you make informed decisions about your health. These options not only improve treatment effectiveness but also offer stability and better absorption. Let’s explore how semaglutide salts can enhance your health and support your journey to wellness.

Ozempic and Exercise: Why It Is Critical to Keep Working Out

It’s tempting to let go of a regular exercise routine when you are on ozempic. However, it can cause major health issues if you only rely on ozempic to lose weight. This article aims to guide you on how to effectively combine Ozempic with a regular exercise routine to maximize health benefits. We'll discuss how exercise enhances the effectiveness of Ozempic, best practices for creating a safe and effective workout regimen, and strategies for overcoming common challenges like weight loss plateaus.

Understanding Ozempic After Gastric Bypass: Potential Side Effects

Ozempic after gastric bypass surgery can be a valuable tool for managing weight and blood sugar levels. In this article, we aim to provide a comprehensive overview of how Ozempic can support post-surgery care. We'll cover its uses, efficacy, and safety profile, along with practical tips for minimizing and managing side effects. Our goal is to give you the knowledge needed to make informed decisions about your treatment and work closely with your healthcare provider. By understanding how Ozempic works and how to manage its use, you can better achieve your health goals and maintain your well-being after gastric bypass surgery.

Zepbound Alternatives: Over-the-Counter and Compounded Tirzepatide

Zepbound (Tirzeparide) is injectable glucagon-like peptide (GLP-1) and gastric inhibitory polypeptide (GIP) agonist approved by FDA for use in obese (BMI≥30) or overweight adults (BMI≥27) with at least one weight-related condition who struggle to reduce body weight by changing diet and regular exercise. However, despite the effectiveness proven by clinical studies due to the high cost, side effects and route of administration it might not be suitable for everyone. In this article we will discuss available alternatives: over-the-counter options and compounded Tirzepatide.

Zepbound vs Mounjaro: Choose the Right Medication for You

Zepbound and Mounjaro belong to the class of medication known as GLP-1 receptor agonists which gained fame thanks to their superior control of blood sugar levels and weight loss effects. Zepbound and Mounjaro are essentially the same medicine prescribed for different health conditions. In this article we will review what the differences are and how to choose between them.

Compounded Tirzepatide: Clinical Insights, Side Effects, and Cost

Tirzepatide, a dual GLP-1/GIP receptor agonist, is an injectable prescription medicine FDA approved for Type 2 diabetes treatment (Mounjaro) and weight management (Zepbound). Compounded Tirzepatide, if it is made to be “essentially a copy”, has the same efficacy and side effects as a commercial counterpart for a fraction of the cost. In this article we will discuss Compounded Tirzepatide dosage and administration, potential side effects, safety and legality and how to choose a reliable Compounding pharmacy.

What Does Zepbound Look Like and How to Spot a Fake

This article guides you through identifying real Zepbound from counterfeits. Knowing the differences can protect you from potential health risks associated with fake drugs. Counterfeit medications often look convincing but lack the effectiveness and safety of genuine products. By understanding key features like packaging, documentation, and physical characteristics, you can confidently verify your medication. This article provides practical steps and tips to help you spot fake Zepbound, ensuring you receive safe and effective treatment. Your health and peace of mind are worth the effort.

Ozempic Dosing Guidelines for Effective Weight Loss

Ozempic is FDA approved prescription drug for glycemic control and reduction of the risk of cardiovascular death, heart attack and stroke in adults with Type 2 diabetes and treatment of nonalcoholic fatty liver disease in people with HIV. Ozempic is widely used as an off-label drug for weight management. A health care provider can prescribe a suitable dose of Ozempic according to the patient's medical history, current conditions and allergies. In this article we will discuss recommended Ozempic dosage for weight loss, dosing schedule and adjustments, side effects and cost of Ozempic.

Comparing Weight Loss Injection Options: Types and Costs

Choosing the right weight loss injection can be overwhelming, especially with so many options available. In this article, we will guide you through different types of weight loss injections, their costs, their effectiveness, and what you need to consider to make an informed decision. You'll explore popular injections like Semaglutide, Tirzepatide, and others, discussing how they work, their benefits, and potential side effects. This article’s goal is to help you understand these treatments better, so you can confidently discuss your options with your healthcare provider. Let's dive in and find the best solution for your weight management needs.

Mounjaro vs. Ozempic: What is the Difference?

How Often Do You Take GLP-1 Agonists?

Typical dosing schedule for injectable GLP-1 medications is once a week (Zepbound, Wegovy, Ozempic), whereas Saxenda and oral Semaglutide (Rybelsus) are taken daily.

Who Can Prescribe GLP-1 for Weight Loss?

Primary care physicians, endocrinologists or doctors who are trained in obesity medicine are the best healthcare professionals to assess health and determine which medication is right.

How Much Do GLP-1 Drugs Cost?

GLP-1 drugs come with a hefty price tag per month if not covered by insurance: Wegovy is $1,349, Zepbound is $1,059 and Saxenda is $1,350. There are assistance programs with discounted prices for Wegovy, Zepbound and Saxenda.

Key Takeaways

GLP-1 agonists are generally well-tolerated, glucose-regulating, satiety-inducing, insulin-sensitizing, pancreatic protective, cardiovascular protective and metabolically beneficial weight-reducing medications.

Wegovy, Zepbound and Saxenda are the most popular among GLP-1 agonists as weight-loss medicines.

GLP-1 agonists are safe to use and show therapeutic benefits as a therapy for Type 1 diabetes.

Always seek medical advice for tailored advice.

Sources

GLP-1 Overview

GLP-1 agonists

Wegovy

Wegovy Clinical Trial